Design and Analysis of Clinical Trials: Concepts and Methodologies

Praise for the Second Edition:

“…a grand feast for biostatisticians. It stands ready to satisfy the appetite of any pharmaceutical scientist with a respectable statistical appetite.” —Journal of Clinical Research Best Practices

The Third Edition of Design and Analysis of Clinical Trials provides complete, comprehensive, and expanded coverage of recent health treatments and interventions. Featuring a unified presentation, the book provides a well-balanced summary of current regulatory requirements and recently developed statistical methods as well as an overview of the various designs and analyses that are utilized at different stages of clinical research and development. Additional features of this Third Edition include:

• New chapters on biomarker development and target clinical trials, adaptive design, trials for evaluating diagnostic devices, statistical methods for translational medicine, and traditional Chinese medicine

• A balanced overview of current and emerging clinical issues as well as newly developed statistical methodologies

• Practical examples of clinical trials that demonstrate everyday applicability, with illustrations and examples to explain key concepts

• New sections on bridging studies and global trials, QT studies, multinational trials, comparative effectiveness trials, and the analysis of QT/QTc prolongation

• A complete and balanced presentation of clinical and scientific issues, statistical concepts, and methodologies for bridging clinical and statistical disciplines

• An update of each chapter that reflects changes in regulatory requirements for the drug review and approval process and recent developments in statistical design and methodology for clinical research and development

Design and Analysis of Clinical Trials, Third Edition continues to be an ideal clinical research reference for academic, pharmaceutical, medical, and regulatory scientists/researchers, statisticians, and graduate-level students.


Design: The Key Concepts (Routledge Key Guides)

This is the essential student’s guide to Design – its practice, its theory and its history. Drawing from a wide range of international examples, respected design writer Catherine McDermott explores key topics including:

  • international design – from Europe to Africa
  • design history – from Art Nouveau to punk
  • sustainable design, recycling and green design
  • design theory – from semiotics to gender, to postcolonialism
  • design technology, graphic design and the web.

Fully cross-referenced, with up-to-date guides for further reading, Design: The Key Concepts is an indispensable reference for students of design, design history, fashion, art and visual culture.


Mechanical Engineering Design: Principles and Concepts

This textbook is designed to serve as a text for undergraduate students of mechanical engineering. It covers fundamental principles, design methodologies and applications of machine elements. It helps students to learn to analyse and design basic machine elements in mechanical systems. Beginning with the basic concepts, the book discusses wide range of topics in design of mechanical elements. The emphasis is on the underlying concepts of design procedures. The inclusion of machine tool design makes the book very useful for the students of production engineering. Students will learn to design different types of elements used in the machine design process such as fasteners, shafts, couplings, etc. and will be able to design these elements for each application. Following a simple and easy to understand approach, the text contains: * Variety of illustrated design problems in detail * Step by step design procedures of different machine elements * Large number of machine design data


Design @Work: Inspiring concepts for contemporary workspaces

Engaging and richly illustrated, this book showcases high-calibre international projects that reveal compelling, contemporary and unconventional workspaces, particularly spaces that redefine where we work and how we work together, and which promote new forms of work, flexibility, creativity and collaboration. Combining rich photography with in-depth descriptions and detailed floor plans, this book helps to illustrate architectural innovation and interior design and how these considerations impact on work culture, be it in unique studio locations to modern office skyscrapers, from work nests and industrious modern activity hives, to warehouse lofts and factory refits, or anything in-between.


Exploring Storyboarding (Design Concepts)

An effective combination of creative exercises, real-life examples, and simple illustrations are integrated in this “how-to” book, teaching readers to develop their storyboarding skills for a variety of media types, including film, television, animation, and interactive media. Each aspect of the storyboarding process is carefully examined including creating visually specific shot lists and overhead diagrams, and drawing simple sketches that express a clear understanding of staging, editing, and composition. Coverage is rounded out with a comprehensive overview of camera techniques that helps readers visualize a scene before the process of storyboarding begins.


Convenience Concepts Designs-2-Go 2-Tier Swivel TV Stand

Practical products from Designs2Go include our 191024 2 tier dobule swivel. Perfect for TV sets and monitors with space for DVD or game players. Convenience Concepts brings you exciting and affordable furniture. Combining exciting designs with economical overseas manufacturing to bring you the finest in sensible contemporary furniture. Focusing on R-T-A Entertainment, TV, Storage, and Accent furniture.


Remediation Engineering: Design Concepts (Geraghty & Miller Environmental Science & Engineering)

In many cases, the application of in situ technologies evolved as a necessity from a cost perspective. However, the basic understanding of the mechanisms and theory behind these technologies was treated as a “black box.” Although we have seen some tremendous successes in the application of remediation technologies over the past several years, we have also seen many cases in which a technology has been incorrectly or inappropriately applied. In most cases, this misapplication has been the result of a poor understanding of the basic concepts and mechanisms behind the technologies. Without proper understanding, the potential for misapplication of technologies remains a serious economic and technical threat.


Design Concepts in Programming Languages (MIT Press)

Hundreds of programming languages are in use today–scripting languages for Internet commerce, user interface programming tools, spreadsheet macros, page format specification languages, and many others. Designing a programming language is a metaprogramming activity that bears certain similarities to programming in a regular language, with clarity and simplicity even more important than in ordinary programming. This comprehensive text uses a simple and concise framework to teach key ideas in programming language design and implementation. The book’s unique approach is based on a family of syntactically simple pedagogical languages that allow students to explore programming language concepts systematically. It takes as premise and starting point the idea that when language behaviors become incredibly complex, the description of the behaviors must be incredibly simple. The book presents a set of tools (a mathematical metalanguage, abstract syntax, operational and denotational semantics) and uses it to explore a comprehensive set of programming language design dimensions, including dynamic semantics (naming, state, control, data), static semantics (types, type reconstruction, polymporphism, effects), and pragmatics (compilation, garbage collection). The many examples and exercises offer students opportunities to apply the foundational ideas explained in the text. Specialized topics and code that implements many of the algorithms and compilation methods in the book can be found on the book’s Web site, along with such additional material as a section on concurrency and proofs of the theorems in the text. The book is suitable as a text for an introductory graduate or advanced undergraduate programming languages course; it can also serve as a reference for researchers and practitioners.